SDF-1 Antibody
Product Details
- Cat. No.
- 251289
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Stromal-Derived Factor (SDF-1) is a chemoattractant active on T-lymphocytes and monocytes, but not neutrophils. This cytokine activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-alpha (3-67) and SDF-1-beta (3-72) show a reduced chemotactic activity. Binding to cell surface proteoglycans inhibits formation of SDF-1-alpha (3-67), preserving the activity of SDF-1 on local sites. SDF-1 acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the Lyn kinase. SDF-1 stimulates migration of monocytes through its receptor, CXCR4, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Chicken, Dog (Canine), Human, Mouse, Pig (Swine), Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human SDF-1.
- Isotype: Rabbit Ig
- Gene: P48061
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)