SH2D1A Rabbit pAb
Product Details
- Cat. No.
- A1143
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
Western blot - SH2D1A antibody (A1143)
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Description
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse
