SHH (8G3) Antibody
Product Details
- Cat. No.
- 253016
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
The supplier does not provide quotations for this antibody through SelectScience. You can search for similar antibodies in our Antibody Directory.
Description
SHH (Sonic hedgehog) is member of the hedgehog signaling pathway. SHH binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Sonic hedgehog is an intercellular signal essential for a variety of patterning events during development, such as ventral cell fate in the neural tube and somites, and for patterning of the anterior-posterior axis of the developing limb bud. Defects in sonic hedgehog has been implicated in eye formation disorders and holoprosencephaly, the most common structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: Purified recombinant fragment of human SHH expressed in E. coli.
- Clone: 8G3
- Isotype: Mouse IgG1
- Gene: Q15465
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- Western Blotting (WB)