SIRT2 rabbit antibody (pAb)
Product Details
- Cat. No.
- 39903
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
SIRT2 is a member of the SIR2 / Sirtuin family of NAD-dependant deacetylase enzymes. It has multiple targets for deacetylation, including Tubulin and many transcription factors, including P53, HOXA10, FOXO3A, P300, FOXO1. SIRT2 suppresses adipogenesis by deacetylating FOXO1, promoting the binding of FOXO1 to PPARγ and subsequent repression of PPARγ mediated transcriptional activation. Similar to SIRT1, also may deacetylate H4AcK16 similar to SIRT1, SIRT2 deacetylates histone H4 at lysine 16. SIRT2 is present in the cytoplasm during most of the cell cycle except in the G2/M transition and in mitosis, where it is found in the nucleus and in contact with chromatin and required for exit from mitosis.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human
- Isotype: IgG
Handling
- Quantity: 100 ul
- Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Applications
- Western Blotting (WB)