SLC8A1 Rabbit pAb
Product Details
- Cat. No.
- A5583
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
Western blot - SLC8A1 antibody (A5583)
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Description
In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human
