Product & ReviewsAntibodies
SMAD6 (5H3) Antibody
Product Details
- Cat. No.
- 253056
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
SMAD6 (Mothers against decapentaplegic homolog 6) protein is an antagonist of signaling by TGF-beta type 1 receptor superfamily members. It has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions. SMAD6 is ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: "Purified recombinant fragment of human SMAD6 expressed in E. coli. <br> <br>"
- Clone: 5H3
- Isotype: Mouse IgG1
- Gene: O43541
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- Western Blotting (WB)