Smad7 Antibody
Product Details
- Cat. No.
- 251212
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Mothers against decapentaplegic homolog 7 (Smad7) is an antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members. Smad7 has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Smad7 functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Smad7 also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Genetic variations in Smad7 influence susceptibility to colorectal cancer type 3 (CRCS3). Colorectal cancer consists of tumors or cancer of either the colon or rectum or both.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Bovine, Human, Mouse, Pig (Swine), Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Smad7.
- Isotype: Rabbit Ig
- Gene: O15105
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)