SMARCA4 rat antibody (mAb) (Clone 5B7), sample
Product Details
- Cat. No.
- 61626
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Rat
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Description
SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4) is the central catalytic ATPase subunit of numerous chromatin-remodeling complexes, including SWI/SNF. These complexes are able to use energy from ATP hydrolysis to physically disrupt chromatin architecture of target promoters and facilitate the binding of transcription factors to nucleosomal DNA. SMARCA4 is a co-regulator of transcription and has been implicated in the activation and repression of gene expression through the modulation of chromatin in various tissues and physiological conditions. This protein plays a major role in many cellular processes such as DNA replication, repair and recombination. Mammalian SMARCA4 is usually associated with approximately 10-12 BAF subunits or other proteins involved in regulation of gene expression. SMARCA4 is part of the stem cell-specific BAF complex, esBAF, and is involved in regulating stem cell pluripotency.
Biological Information
- Clonality: Monoclonal
- Host: Rat
- Reactivity: Human, Monkey, Mouse
- Clone: 5B7
- Isotype: IgG2a
Handling
- Quantity: 10 ug
- Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Applications
- Immunocytochemistry (ICC)
- Immunofluorescence (IF)
- Western Blotting (WB)