Product & ReviewsAntibodies

SMARCAL1 / HARP mouse antibody (mAb) (Clone 4B10)

Product Details

Cat. No.
61115
Type
Primary Antibody
Clonality
Monoclonal
Host
Mouse
Active Motif

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Description

SMARCAL1 / HARP (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1, HepA-related protein, DNA-dependent ATPase A) is a member of the SWI / SNF family of ATPases and chromatin remodeling proteins. Unlike other SWI / SNF family members, SMARCAL1 / HARP has not been shown to remodel chromatin, but possesses an ATP-dependent annealing helicase activity. SMARCAL1 reanneals single stranded DNA bubbles in DNA at DNA replication forks that are bound by Replication Protein A (RPA). Defects in SMARCAL1 / HARP are a cause of Schimke immuno-osseous dysplasia (SIOD) SIOD causes spondyloepiphyseal dysplasia (a disorder of bone growth that results in short stature, skeletal abnormalities, and problems with vision and hearing), renal dysfunction and T-cell immunodeficiency.

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Bovine, Human, Mouse
  • Clone: 4B10
  • Isotype: IgG1

Handling

  • Quantity: 100 ug
  • Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Applications

  • Immunoprecipitation (IP)
  • Western Blotting (WB)
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