SMARCAL1 / HARP mouse antibody (mAb) (Clone 4B10), sample
Product Details
- Cat. No.
- 61116
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
SMARCAL1 / HARP (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1, HepA-related protein, DNA-dependent ATPase A) is a member of the SWI / SNF family of ATPases and chromatin remodeling proteins. Unlike other SWI / SNF family members, SMARCAL1 / HARP has not been shown to remodel chromatin, but possesses an ATP-dependent annealing helicase activity. SMARCAL1 reanneals single stranded DNA bubbles in DNA at DNA replication forks that are bound by Replication Protein A (RPA). Defects in SMARCAL1 / HARP are a cause of Schimke immuno-osseous dysplasia (SIOD) SIOD causes spondyloepiphyseal dysplasia (a disorder of bone growth that results in short stature, skeletal abnormalities, and problems with vision and hearing), renal dysfunction and T-cell immunodeficiency.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Bovine, Human, Mouse
- Clone: 4B10
- Isotype: IgG1
Handling
- Quantity: 10 ug
- Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Applications
- Immunoprecipitation (IP)
- Western Blotting (WB)