SOCS-1 Antibody
Product Details
- Cat. No.
- 250862
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
The supplier does not provide quotations for this antibody through SelectScience. You can search for similar antibodies in our Antibody Directory.
Description
SOCS family proteins form part of a classical negative feedback system that that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs it inhibits their kianse activity. In vitro, they also supresses Tec protein-tyrosine activity. SOCS1 appears to be a major regulator of interleukin 6 (IL6) and leukemia inihibitory factor (LIF) signaling. SOCS-1 regulates interferon-gamma mediated sensory neuron survival. It is also implicated, through SOCS box binding, in ubiquitin-dependent protein degradation. There is high expression in thymus, and lower expression in lung and spleen.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human SOCS-1.
- Isotype: Rabbit Ig
- Gene: O15524
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)