Product & ReviewsAntibodies

Sox2 Antibody

Product Details

Cat. No.
254505
Type
Primary Antibody
Clonality
Polyclonal
Host
Rabbit
Abbiotec

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Description

Transcription factor SOX-2 (Sox2) forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Defects in Sox2 are the cause of microphthalmia syndromic type 3 (MCOPS3). Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. POU5F1/OCT4, Sox2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes.

Biological Information

  • Clonality: Polyclonal
  • Host: Rabbit
  • Reactivity: Bovine, Dog (Canine), Human, Mouse, Pig (Swine), Rabbit (Lapine), Rat, Sheep (Ovine)
  • Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Sox2.
  • Conjugate: FITC-conjugated Antibody
  • Isotype: Rabbit Ig
  • Gene: P48431

Handling

  • Quantity: 0.1 mg
  • Storage: Store at 4°C. Product is guaranteed 6 months from the date of shipment.

Applications

  • Immunofluorescence (IF)
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