SRC (4F1E) Antibody
Product Details
- Cat. No.
- 252767
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
c-Src (Proto-oncogene tyrosine-protein kinase Src) is a non-receptor protein tyrosine kinase. It plays pivotal roles in numerous cellular processes such as proliferation, migration and transformation. In concert with PTK2B, c-Src plays an important role in osteoclastic bone resorption. Both the formation of a SRC-PTK2B complex and c-SRC kinase activity are necessary for this function. Once it is recruited to the activated integrins by PTK2B, c-Src phosphorylates CBL which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. C-Src promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: Purified recombinant fragment of SRC(aa10-193) expressed in E. coli.
- Clone: 4F1E8
- Isotype: Mouse IgG2b
- Gene: P12931
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- Western Blotting (WB)