Product & ReviewsAntibodies

SRC (4F1E) Antibody

Product Details

Cat. No.
252767
Type
Primary Antibody
Clonality
Monoclonal
Host
Mouse
Abbiotec

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Description

c-Src (Proto-oncogene tyrosine-protein kinase Src) is a non-receptor protein tyrosine kinase. It plays pivotal roles in numerous cellular processes such as proliferation, migration and transformation. In concert with PTK2B, c-Src plays an important role in osteoclastic bone resorption. Both the formation of a SRC-PTK2B complex and c-SRC kinase activity are necessary for this function. Once it is recruited to the activated integrins by PTK2B, c-Src phosphorylates CBL which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. C-Src promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase.

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Human
  • Antigen: Purified recombinant fragment of SRC(aa10-193) expressed in E. coli.
  • Clone: 4F1E8
  • Isotype: Mouse IgG2b
  • Gene: P12931

Handling

  • Quantity: 0.1 ml
  • Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.

Applications

  • Western Blotting (WB)
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