Product & ReviewsAntibodies
SREBP-2 mouse antibody (mAb) (Clone IgG-1C6)
Product Details
- Cat. No.
- 39941
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
SREBP-1 and SREBP-2 (Sterol regulatory element-binding protein 1 and 2) are members of the basic-helix-loop-helix-leucine zipper (bHLH-ZIP) family of transcription factors and are involved in the regulation of cholesterol homeostasis. SREBP-1 and SREBP-2 are normally membrane bound at the ER and nuclear envelope, but in sterol-depleted cells, the membrane-bound precursors are cleaved to generate a soluble isoforms that translocate to the nucleus. These active forms, which includes the bHLH-ZIP domain, activate transcription of genes involved in the uptake and synthesis of cholesterol.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Clone: IgG-1C6
- Isotype: IgG
Handling
- Quantity: 100 ug
- Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Applications
- Chromatin Immunoprecipitation (ChIP)
- Western Blotting (WB)