Product & ReviewsAntibodies

SRF rat antibody (mAb) (Clone 2C5)

Product Details

Cat. No.
61385
Type
Primary Antibody
Clonality
Monoclonal
Host
Rat
Active Motif

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Description

SRF (serum response factor) is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs).

Biological Information

  • Clonality: Monoclonal
  • Host: Rat
  • Reactivity: Human, Mouse
  • Clone: 2C5
  • Isotype: IgG2a

Handling

  • Quantity: 100 ug
  • Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Applications

  • Chromatin Immunoprecipitation (ChIP)
  • Immunohistochemistry (IHC)
  • Western Blotting (WB)
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