Product & ReviewsAntibodies
STAT5B (5B3) Antibody
Product Details
- Cat. No.
- 253034
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
STAT5 (Signal transducer and activator of transcription 5A) carries out a dual function: signal transduction and activation of transcription. STAT5 is tyrosine phosphorylated in response to IL-2, IL-3, IL-7, IL-15, GM-CSF, growth hormone, prolactin, erythropoietin and thrombopoietin. Phosphorylation results in translocation into the nucleus, where it binds to the GAS element and activates transcription. Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: "Purified recombinant fragment of human STAT5B expressed in E. coli. <br>"
- Clone: 5B3
- Isotype: Mouse IgG1
- Gene: P42229
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- Western Blotting (WB)