Product & ReviewsAntibodies
Survivin Antibody
Product Details
- Cat. No.
- 250529
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Apoptosis inhibitor survivin, also called baculoviral IAP repeat-containing protein 5 (BIRC5), is a component of the chromosomal passenger complex (CPC), a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation. CPC is required for chromatin-induced microtubule tabilization and spindle assembly. Survivin interacts with tubulin and inhibits caspase-3 and caspase-7. Survivin is abundantly expressed in adenocarcinoma and high-grade lymphomas.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Survivin.
- Isotype: Rabbit Ig
- Gene: O15392
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)