SYK (8C1A) Antibody
Product Details
- Cat. No.
- 252775
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
SYK (Spleen tyrosine kinase), along with Zap-70, is a member of the Syk family of cytoplasmic tyrosine kinases, containing a dual SH2 domain separated by a linker region. In B cells, SYK couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through phosphorylation/activation of phospholipase C-gamma, when phosphorylated on Tyr-348 and Tyr-352. Phosphorylation on Tyr-323 creates a binding site for c-Cbl, which is a negative regulator of BCR-stimulated calcium signaling. Also transmits signals from other cell surface receptors including the T-cell receptor, CD74, Fc receptor and integrins. Abnormal constitutive SYK activity has been implicated in some hematopoietic malignancies.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: Purified recombinant fragment of SYK(aa296-484) expressed in E. coli.
- Clone: 8C1A3
- Isotype: Mouse IgG1
- Gene: P43405
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- Western Blotting (WB)