SYK Antibody
Product Details
- Cat. No.
- 250530
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
The supplier does not provide quotations for this antibody through SelectScience. You can search for similar antibodies in our Antibody Directory.
Description
SYK (Spleen tyrosine kinase), along with Zap-70, is a member of the Syk family of cytoplasmic tyrosine kinases that contain a dual SH2 domain separated by a linker region. In B cells, SYK couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through phosphorylation/activation of phospholipase C-gamma, when phosphorylated on Tyr-348 and Tyr-352. Phosphorylation on Tyr-323 creates a binding site for c-Cbl, which is a negative regulator of BCR-stimulated calcium signaling. Also transmits signals from other cell surface receptors including the T-cell receptor, CD74, Fc receptor, and integrins. Abnormal constitutive SYK activity has been implicated in some hematopoietic malignancies.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Bovine, Dog (Canine), Human, Mouse, Pig (Swine), Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human SYK.
- Isotype: Rabbit Ig
- Gene: P43405
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)