Product & ReviewsAntibodies
TAB2 (3B5) Antibody
Product Details
- Cat. No.
- 253082
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
TAB2 (TGF-beta-activated kinase 1 and MAP3K7-binding protein 2) is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. TAB2 with TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: Purified recombinant fragment of human TAB2 expressed in E. coli.
- Clone: 3B5
- Isotype: Mouse IgG1
- Gene: Q9NYJ8
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- ELISA (ELISA)
- Flow Cytometry (FC)
- Western Blotting (WB)