Product & ReviewsAntibodies
TCF-4 Antibody
Product Details
- Cat. No.
- 251642
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
T-cell-specific transcription factor 4 (TCF-4) participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. TFC-4 acts as repressor in the absence of CTNNB1, and as activator in its presence. TCF-4 is necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. Genetic variations in TCF-4 are associated with susceptibility to non-insulin-dependent diabetes mellitus (NIDDM). NIDDM is characterized by an autosomal dominant mode of inheritance, onset during adulthood and insulin resistance.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Pig (Swine), Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human TCF-4.
- Isotype: Rabbit Ig
- Gene: Q9NQB0
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Immunoprecipitation (IP)
- Western Blotting (WB)