Product & ReviewsAntibodies

TCF7L1 / TCF3 rabbit antibody (pAb)

Product Details

Cat. No.
61125
Type
Primary Antibody
Clonality
Polyclonal
Host
Rabbit
Active Motif

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Description

TCF3 / TCF7L1 (T-cell factor 3, TCF7L1) is a member of the TCF/LEF family and a component of the Wnt signaling pathway and a dominant downstream effector in embryonic stem cells (ESCs). TCF3 binds to DNA and serves as both a repressor as well as an activator of transcription. TCF3 brings developmental signals directly to the core regulatory circuitry of ES cells to influence the balance between pluripotency and differentiation. TCF3 transcriptionally represses many genes important for maintaining pluripotency and self-renewal, as well as those involved in lineage commitment and stem cell differentiation. This effect is in part mediated by the corepressors transducin-like enhancer of split 2 (TLE2) and C-terminal Binding Protein (CtBP).

Biological Information

  • Clonality: Polyclonal
  • Host: Rabbit
  • Reactivity: Human
  • Isotype: IgG

Handling

  • Quantity: 100 ul
  • Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Applications

  • Chromatin Immunoprecipitation (ChIP)
  • Western Blotting (WB)
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