Product & ReviewsAntibodies
TDG / Thymine-DNA glycosylase rabbit antibody (pAb)
Product Details
- Cat. No.
- 61437
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. In addition, TET proteins oxidize 5- methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5- formylcytosine (5fC), and 5-carboxylcytosine (5caC). TDG / Thymine-DNA glycosylase functions to correct G/T mispairs to G/C pairs and plays a role in active DNA demethylation by recognizing 5fC and 5caC and converting these to cystosine through the base excision repair (BER) pathway.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Mouse
- Isotype: IgG
Handling
- Quantity: 100 ul
- Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Applications
- Western Blotting (WB)