Product & ReviewsAntibodies
TDP-43 Antibody
Product Details
- Cat. No.
- 251318
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
TAR DNA-binding protein 43 (TDP-43) is a DNA and RNA-binding protein which regulates transcription and splicing. TDP-43 is involved in the regulation of CFTR splicing, and promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. TDP-43 is also involved in microRNA biogenesis, apoptosis, and cell division. TDP-43 can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Bovine, Chicken, Human, Mouse, Rabbit (Lapine), Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human TDP-43.
- Isotype: Rabbit Ig
- Gene: Q13148
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)