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Testicular receptor 2 (TR2) is a member of the orphan nuclear receptor family. TR2 is widely expressed at a low level throughout the adult testis. TR2 represses transcription and binds DNA, directly interacting with HDAC3 and HDAC4 via DNA-binding domains. TR2 has also been implicated in regulation of estrogen receptor activity in mammary glands. TR2 forms a heterodimer with TR4 that can bind to the direct repeat 6 element of the hepatitis B virus (HBV) enhancer II region thus suppressing HBV gene expression.