TGF-beta 1 Antibody
Product Details
- Cat. No.
- 250876
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
The TGF-beta superfamily is composed of numerous growth differentiation factors, including transforming growth factor beta 1, 2 , and 3 (TGF-beta 1, TGF-beta 2 and, TGF-beta 3). TGF-beta 1 controls proliferation, differentiation and other functions in many cell types. TGF-beta 1 is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. The inactive form consists of a TGF-beta 1 homodimer non-covalently linked to a latency-associated peptide (LAP) homodimer. The active form is a disulfide-linked homodimer of mature TGF-beta 1. Defects in TGF-beta 1 are the cause of Camurati-Emgelmann disease, a progressive diaphyseal dysplasia characterized by hyperostosis ans sclerosis of the diaphyses of long bones.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human TGF-beta 1.
- Isotype: Rabbit Ig
- Gene: P01137
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)