Product & ReviewsAntibodies
TGF-beta Receptor Type I Antibody
Product Details
- Cat. No.
- 250879
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
TGF-beta receptor type I (TGFR1) forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors that autophosphorylate and activate SMAD transcriptional regulators. Although TGFR1 is ubiquitously expressed, it is found most abundant in placenta and least abundant in brain and heart. Defects in TGFBR1 are the cause of Loeys-Dietz syndrome type 1 and 2 (aortic aneurysm syndromes).
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Bovine, Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human TGFR1.
- Isotype: Rabbit Ig
- Gene: P36897
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)