Product & ReviewsAntibodies
TIE-2 Antibody
Product Details
- Cat. No.
- 251663
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
The TEK receptor tyrosine kinase (TIE2) is expressed almost exclusively in endothelial cells in mice, rats, and humans. The TIE2 receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for TIE2 is angiopoietin-1. The TIE2 signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. Defects in TIE2 are associated with inherited venous malformations.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Pig (Swine), Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of rat TIE2.
- Isotype: Rabbit Ig
- Gene: Q02763
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)