Product & ReviewsAntibodies
TNF-R2 Antibody
Product Details
- Cat. No.
- 250107
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
Tumor necrosis factor receptor 2 (TNF-R2) is a high-affinity receptor for TNF-alpha and a low-affinity receptor for lymphotoxin-alpha. TNF-R2 has two isoforms produced by alternative splicing: a cell membrane and a secreted form. The latter blocks TNF-alpha-induced apoptosis, which suggests that this isoform regulates TNF-alpha function by antagonizing its biological activity. A soluble fragment of TNF-R2 (Enbrel, Immunex and Wyeth-Ayerst) is used as treatment of moderate and severe rheumatoid arthritis. This antibody recognizes human TNF-R2 in ELISA and flow cytometry.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: Recombinant soluble human TNF-R2-Fc fusion protein
- Clone: KT30
- Isotype: mouse IgG2a
- Gene: P20333, NP_001057
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Flow Cytometry (FC)