Product & ReviewsAntibodies

TNFα-AF700, IPM2, 0.5 mL, ASR

Product Details

Cat. No.
B76295
Type
Flow Cytometry Reagents
Clonality
Monoclonal
Host
Mouse
Beckman Coulter Life Sciences

The supplier does not provide quotations for this antibody through SelectScience. You can search for similar antibodies in our  Antibody Directory.

Description

Tumor necrosis factor α (TNFα) or cachectin is a cytokine that was first identified based on its cytotoxic activity against various cell lines and tumor cells. Human TNFα is synthesized as a pro-protein with a molecular weight of 26 kDa (membrane-bound form). The pro-protein is cleaved by a specific metalloprotease (TACE) yielding a monomeric, soluble form of 17 kDa. Under physiological conditions, TNFα forms a homotrimeric protein. This cytokine is primarily produced by mononuclear phagocytes, and by activated lymphocytes. Immunostaining allows intracellular detection of TNFα before it can be detected by a bioassay. TNFα acts on target cells by binding to two types of receptors, the TNFα receptor I (TNF-RI or CD120a) and the TNFα receptor II (TNF-RII or CD120b). TNFα elicits a wide spectrum of immune and inflammatory responses, including the induction of other cytokines and immunoregulatory molecules, cell growth and differentiation and apoptosis. This molecule is also involved in Th1 - Th2 (T helper 1 - T helper 2) cytokine pathways (or Type 1 - Type 2 responses), as a Th1-effector cytokine. *Alexa Fluor and Pacific Blue are registered trademarks of Molecular Probes, Inc.

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Human
  • Antigen: TNFα
  • Clone: IPM2
  • Conjugate: Alexa Fluor* 700
  • Isotype: IgG1

Handling

  • Quantity: 0.5 mL

Applications

  • Flow Cytometry (FC)
Specificity rating
Sensitivity rating
Quality rating
Write your own review

Product Overview

Links