Product & ReviewsAntibodies
TNFRSF11B (5A11) Antibody
Product Details
- Cat. No.
- 253095
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
OPG (Osteoprotegerin) is a decoy receptor for RANKL by neutralizing its function in osteoclastogenesis. OPG inhibits osteoclast activation and promotes osteoclast apoptosis in vitro. OPG is up-regulated by increasing calcium concentration and estrogens. Defects in OPG are the cause of juvenile Paget disease, which is characterized by rapid bone remodeling leading to deformities, fractures and osteopenia.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: Purified recombinant fragment of human TNFRSF11B expressed in E. coli.
- Clone: 5A11
- Isotype: Mouse IgG1
- Gene: O00300
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- Immunohistochemistry (IHC)
- Western Blotting (WB)