TNK1 (1B5G) Antibody
Product Details
- Cat. No.
- 252782
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
TNK1 (Tyrosine kinase, non-receptor, 1) is a nonreceptor tyrosine kinase (NRPTK). These kinases, like members of the SRC (MIM 190090) and JAK (see MIM 147795) families, mediate intracellular signaling downstream of receptor activation. Tnk1 is a ubiquitously expressed 47-kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Tnk1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Tnk1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: "Purified recombinant fragment of TNK1(aa451-560) expressed in E. coli. <br>"
- Clone: 1B5G3;3F11H6
- Isotype: Mouse IgG1
- Gene: Q13470
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- Western Blotting (WB)