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Transthyretin (TTR or prealbumin) is a major thyroid-hormone binding protein involved in transporting thyroxine from the bloodstream to the brain. Sequence variants of Transthyretin have been identified in amyloid fibrils from patients with familial amyloidotic polyneuropath (FAP), the most common form of hereditary systemic amyloidosis. Transthyretin is mostly expressed in the choroid plexus but is also found in the liver.