Trim5 alpha (3B11) Antibody
Product Details
- Cat. No.
- 252615
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
TRIM5-alpha (Tripartite motif-containing protein 5) is a protein that is found in the cells of many mammals and fends off various retrovirus infections. It protects monkeys from infection with HIV-1 and humans from infection with some other viruses. If a retrovirus has entered a cell, it needs to shed its capsid in order to reversely transcribe its genes, so that they can be expressed by the host cell. It is believed that TRIM5 alpha, which is present in the cytoplasm, somehow recognizes the capsid and blocks its shedding, thereby stopping the virus in its tracks. It thus represents an intracellular defense completely separate from the rest of the body's immune system.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: Purified recombinant fragment of human trim5 alpha expressed in E. coli.
- Clone: 3B11H2
- Isotype: Mouse IgG1
- Gene: Q9C035
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- Immunohistochemistry (IHC)
- Western Blotting (WB)