TrkA (6B2) Antibody
Product Details
- Cat. No.
- 252878
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
TrkA is a 140-kDa cell surface receptor (gp140) expressed in neurons of the sensory spinal and cranial ganglia of neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of TrkA in neural cell lines and embryonic dorsal root ganglia. TrkA is a receptor of high-affinity for NGF, neurotrophin-3 and neurotrophin 4/5 but not BDNF. TrkA exists in a dynamic equilibrim between monomeric (low affinity) and dimeric (high affinity) structures. TrkA has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Defects in TrkA are a cause of congenital insentivity to pain with anhidrosis. Chromosomal aberrations involving TrkA are a cause of thyroid papillary carcinoma.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: Purified recombinant extracellular fragment of human TrkA(aa33-423) fused with hIgGFc tag expressed in HEK293 cell line.
- Clone: 6B2
- Isotype: Mouse IgG1
- Gene: P04629
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- Immunofluorescence (IF)
- Western Blotting (WB)