UBE1L (5B10) Antibody
Product Details
- Cat. No.
- 253054
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
UBE1L (Ubiquitin-activating enzyme E1 homolog UBE1L) a member of the E1 ubiquitin-activating enzyme family. Modification of proteins with ubiquitin is an important cellular mechanism for targeting. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases or E3s. UBE1L is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. UBE1L is expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines abnormal or short-lived proteins for degradation.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: Purified recombinant fragment of human UBE1L expressed in E. coli.
- Clone: 5B10
- Isotype: Mouse IgG1
- Gene: P41226
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- Western Blotting (WB)