Product & ReviewsAntibodies
UCHL1 Antibody
Product Details
- Cat. No.
- 253236
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Chicken
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Description
Ubiquitin C-terminal hydrolase 1 (UCHL1) cleaves ubiquitin from other molecules. Genetic knockout of UCHL1 in mice results in a motor neuron degeneration similar to the spontaneous gracile axonal dystrophy (gad) mutant mice. Point mutations in the UCHL1 gene are associated with some forms of human Parkinson's disease. Since UCHL1 is heavily expressed in neurons, it is released in large amounts following injury or degeneration. The detection of UCHL1 in CSF and other bodily fluids can be used as a biomarker.
Biological Information
- Clonality: Polyclonal
- Host: Chicken
- Reactivity: Bovine, Human, Mouse, Rat
- Antigen: Recombinant full length human UCHL1 expressed in E. coli.
- Isotype: Chicken Ig
- Gene: P09936
Handling
- Quantity: 0.1 ml
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunofluorescence (IF)
- Western Blotting (WB)