UHRF1 Antibody (H-8)

UHRF1 Antibody (H-8) is a high quality monoclonal UHRF1 antibody (also designated UHRF1 antibody) suitable for the detection of the UHRF1 protein of mouse, rat and human origin. UHRF1 Antibody (H-8) is available as both the non-conjugated anti-UHRF1 antibody form, as well as multiple conjugated forms of anti-UHRF1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1), also known as Np95 (nuclear zinc finger protein 95), ICBP90 (inverted CCAAT box-binding protein of 90 kDa) or RNF106, is a transcription and cell cycle regulator belonging to the RING-finger type E3 ubiquitin ligase subfamily. UHRF1 is expressed in bone marrow, thymus, heart, testis and lung, and contains one PHD-type zinc finger, a ubiquitin-like domain, two RING-type zinc fingers and one YDG/SRA domain. Localizing to the nucleus, UHRF1 is believed to function as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfers that residue to a protein that is targeted for degradation. By mediating ubiquitination, UHRF1 plays an important role in cellular proliferation. In addition, UHRF1 directly interacts with Dnmt1 (a maintenance DNA methyltransferase) and is required for the stable association of Dnmt1 with chromatin. UHRF1 is overexpressed in cancer cells, suggesting a possible role in carcinogenesis. For Research Use Only. Not Intended for Diagnostic or Therapeutic Use. Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA. LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

• Clonality: Monoclonal
• Host: Mouse
• Reactivity: Human, Mouse, Rat

• Specificity: 5

• ELISA (ELISA)
• Immunofluorescence (IF)
• Immunohistochemistry (Paraffin-Embedded Sections) (IHC (P))
• Immunoprecipitation (IP)
• Western Blotting (WB)