UHRF1 Rabbit pAb
Product Details
- Cat. No.
- A12589
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
Western blot - UHRF1 antibody (A12589)
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Description
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Mouse
