VDAC-1 Antibody
Product Details
- Cat. No.
- 251931
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Voltage-dependent anion-selective channel protein 1 (VDAC-1) forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; whereas in the plasma membrane it is involved in cell volume regulation and apoptosis. VDAC-1 adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has weak anion selectivity whereas the closed state is cation-selective. VDAC-1 participates in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human VDAC-1.
- Isotype: Rabbit Ig
- Gene: P21796
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Western Blotting (WB)