Vinculin Antibody
Product Details
- Cat. No.
- 251810
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
In mammalian cells, vinculin is a membrane-cytoskeletal protein in focal adhesion plaques that is involved in linkage of integrin adhesion molecules to the actin cytoskeleton. Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in inculin are the cause of cardiomyopathy dilated type 1W (CMD1W). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Chicken, Human, Mouse, Rat
- Antigen: Human vinculin, purified from uterus.
- Clone: VIN-54
- Isotype: Mouse IgG1
- Gene: P18206
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)