Product & ReviewsAntibodies
ZAP-70-PE, SBZAP, 1 mL, ASR
Product Details
- Cat. No.
- B10248
- Type
- Flow Cytometry Reagents
- Clonality
- Monoclonal
- Host
- Mouse
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Description
Zap-70, a Syk family protein tyrosine kinase expressed in T and NK cells, plays a critical role in mediating T cell activation in response to T cell receptor (TCR) engagement. Following TCR engagement, Zap-70 is rapidly phosphorylated on several tyrosine residues, presumably by two mechanisms: autophosphorylation and transphosphorylation by the Src family tyrosine kinase, Lck. Tyrosine phosphorylation of Zap-70 correlates with its increased kinase activity and downstream signaling events.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: ZAP-70
- Clone: SBZAP
- Conjugate: PE
- Isotype: IgG1
Handling
- Quantity: 1 mL
Applications
- Flow Cytometry (FC)