ZAP70 (3D2A) Antibody
Product Details
- Cat. No.
- 252649
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
ZAP70 (Zeta-chain associated protein kinase) is a 70 kDa member of the SYK tyrosine kinase family. It plays a central role in lymphocyte activation and development, implicated in several immune disorders. ZAP70 controls TCR (T-cell antigen receptor)-linked signal transduction pathways. Its key role in thymocytes development and mature T lymphocytes activation has been illustrated by the characterization of several human immunodeficiencies presenting with mutations in the ZAP70 gene. ZAP70 is also expressed in several types of B-cell neoplasm and is easily detected by immunohistochemistry, providing a useful prognostic marker in patients with chronic lymphocytic leukaemia.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: Purified recombinant fragment of human ZAP70 expressed in E. coli.
- Clone: 3D2A4
- Isotype: Mouse IgG1
- Gene: P43403
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- Immunohistochemistry (IHC)
- Western Blotting (WB)