Isolation of Enzyme Active Site-Specific Recombinant Antibodies by Guided Selection

In this application note, Bio-Rad demonstrates how the Human Combinatorial Antibody Library (HuCAL^®) technology was used to isolate antibodies specific to the active site of the West Nile Virus NS2B-NS3 proteinase complex, providing antibody research tools that enabled scientists to carry out inhibition experiments and structural studies.