From AI to artificial lifeforms, we spotlight the latest research and automation solutions innovating life sciences and drug discovery
17 May 2020
Tom Casburn
Associate Editor
Enhancing target discovery and accelerating drug development
Dr. Shushant Jain discusses how reprogramed glutamatergic cortical neurons from Bit Bio can be used to enhance early target discovery and accelerate drug discovery.
Increasing the accuracy of testing for anti-cancer therapeutics In this video, zPREDICTA CEO and founder, Dr. Julia Kirshner, discusses the benefits of using Tecan's D300e Digital Dispenser for combination treatments in cell cultures to develop laboratory models for more accurate testing of anti-cancer therapeutics. A new approach for monitoring protein kinases and phosphatases In this presentation, Carl Peters, from BMG LABTECH, and Erik Schaeffer, from AssayQuant Technologies, Inc., discuss the exciting area of protein kinases as a target class and highlight the microplate reader technology supporting this collaboration. Fulfilling the potential of emerging trends in life sciences David Newble, Managing Director of SPT Labtech, discusses emerging trends and novel techniques in life sciences and drug discovery and how unique technologies and automation solutions from SPT Labtech are set to transform the efficiency of laboratory workflows. From next-generation sequencing (NGS) miniaturization to the expansion of cryo-electron microscopy and the networking of automated biobanking, find out what could soon be changing in and around your lab. Dragonfly dispensing in drug discovery Merck scientists Tina Minnick and Liudmila Dzhekieva share examples of how the dragonfly discovery liquid handler from SPT Labtech has proved advantageous for a range of drug discovery applications. Design of Experiments (DOE) automation for robust, high-throughput methodology In this video, Shama Chilakwad, an EngD candidate at Synthace Ltd., describes how SPT Labtech's dragonfly discovery automated the execution of an experiment that used a Design of Experiments (DOE) framework. Collaboration creating solutions for complex pre-analytical workflows In this video, Nigel Skinner, Andrew Alliance, and Stephen Calciano, Waters, discuss Waters’ acquisition of Andrew Alliance and how it will lead to an acceleration in the development of solutions for complex analytical workflows across the industry, highlighting the automation of Waters protocols on OneLab software and the Andrew+ pipetting robot. The story behind the launch of high-throughput screening at Sygnature Discovery Denise Swift, senior scientist at Sygnature Discovery, discusses how high-throughput screening (HTS) was established at Sygnature Discovery. HTS was introduced to offer a more comprehensive integrated hit-discovery platform to enhance successful early drug discovery for their clients. Working side by side with scientists to devise the best lab products Chris Waddling, a field application scientist with SPT Labtech, discusses the importance of working closely with customers in order to ensure that the lab products it develops enable scientists to work effectively and get the most accurate data possible. BioAccord LC-MS System announced Best New Product of 2019 Scientists from around the world chose the Waters BioAccord LC-MS System as the Best New Drug Discovery & Development Product of 2019. In this video, Selena Larkin, a Senior Director at Waters Corporation, shares what it means to win this prestigious award, how the system is helping scientists working in biopharmaceuticals, and what to look out for next from Waters. Pioneering scientists share their research on The Scientists' Channel Melanie Leveridge, GlaxoSmithKline Trends in drug discovery: From cellular target engagement technologies to AI disrupting pharmaceutical developments Melanie Leveridge, SLAS2020 Co-Chair and Head of Screening, Profiling & Mechanistic Biology, GSK, explores the hot drug discovery trends at SLAS2020. Leveridge also predicts the topics that will make an impact at SLAS2021, including omics technology and cell therapy. The future of morphological profiling databases Dr. Anne Carpenter, Institute Scientist and Imaging Platform Senior Director, Broad Institute of MIT and Harvard, discusses her work on a cell painting assay project, aiming to extract the most information out of microscopy images in order to use this as a signature of how cells are responding to disease and treatments. AI accelerates drug discovery and development through data mining Dr. Jackie Hunter, board member of BenevolentAI, explains why artificial intelligence (AI) will be transformational for drug discovery and drug development and how it can enhance diagnosis to rapidly detect cancer and other diseases. Prof. Lee Cronin, University of Glasgow Digitizing chemistry to create artificial lifeforms Lee Cronin, Regius Professor of Chemistry at the University of Glasgow, tells The Scientists’ Channel about the Cronin Group’s far-reaching project exploring the origin of life and its objectives to create artificial lifeforms, discover aliens and work out how to digitize chemistry. Microfluidic devices for intracellular delivery In this video, Dr. Aram Chung, associate professor at Korea University, discusses his team's groundbreaking work creating microscale fluid-flow solutions for biologists and physicians, especially those involved in cancer immunotherapy. Microbiological analysis systems for the identification of bacteria Prof. Pak Kin Wong, Professor of Biomedical Engineering, Mechanical Engineering, and Surgery at the Pennsylvania State University, describes his current work developing comprehensive microbiology analysis systems designed to provide rapid pathogen identification and antimicrobial susceptibility testing within samples. Prof. Kevin Eggan, Harvard Stem Cell Institute Stem cell research: Elucidating the molecular mechanisms of psychiatric conditions Prof. Kevin Eggan, Harvard Stem Cell Institute, reveals how new experiments are elucidating the genetic, cellular and molecular mechanisms in psychiatric diseases like schizophrenia. Hear about the latest trends in stem cell technologies and how these are starting to be translated to new therapeutics and cures for diseases. Biofabrication of human tissue for the development of personalized medicine and regeneration of organs Dr. Shrike Zhang, Assistant Professor, Harvard Medical School & Associate Bioengineer, Brigham and Women’s Hospital, discusses his research on biofabrication of human tissues. Zhang describes how the bioprinters used in this work are developed by extrusion and layer-by-layer techniques, in order to provide engineered tissue for the structural regeneration of tissues for patients with disease and for the provision of models for drug testing. Watch more videos on The Scientists' Channel>>
