A method for preparing tumor tissues for ex vivo culture that retains T cells within live tumor fragments (LTFs) while preserving tissue viability and T cell function

Traditional tissue preparation methods can disrupt the tumor microenvironment (TME), which poses challenges for characterizing responses to immunotherapy in live tumor fragments (LTFs).

In this scientific poster, Elephas Biosciences presents a method that incorporates automated cutting instruments designed to optimally fragment tumor resections and core needle biopsies (CNBs), and a proprietary hydrogel that supports the TME of LTFs in ex vivo culture.