Accelerate your LNP formulation screening with Sunscreen’s automated microfluidic technology

In this application note, Unchained Labs introduces a high-throughput screening solution, Sunscreen, designed to accelerate the formulation screening process for lipid nanoparticles (LNPs). LNPs are pivotal in the clinical delivery of nucleic acids and hold immense potential for rapid translation from concept to clinic, as evidenced by the swift development of COVID-19 vaccines like Spikevax^® (Moderna^®). Despite their effectiveness, LNPs are complex, requiring careful selection of specific lipids and precise ratios for successful RNA binding and delivery. With over 18 LNP-based products currently in clinical trials, the field is rapidly evolving, incorporating diverse materials and complex components, including passive and active targeting strategies for specific organ and cell type delivery. Sunscreen streamlines this intricate formulation process, enabling 96 automated experiments in under six hours, thereby boosting efficiency and paving the way for future discoveries in drug development.