Automated Sample Preparation for Tablet Analysis: Metrohm's 815 Robotic Soliprep

Before ingredients in pharmaceutical tablets can be determined, sample preparation steps have to be performed that require substantial effort. Automation with Metrohm's 815 Robotic Soliprep speeds up sample preparation while improving reproducibility and accuracy.

Sample preparation can slow you down
The production of pharmaceutical tablets requires proof that the active ingredient content given on the package is valid for each single tablet of a batch. Various analytical techniques such as titration or ion chromatography are used for the highly accurate quantitation of the ingredients. Depending on the shape, coating, auxiliary components used and the concentration of the pharmaceutical ingredient, different sample preparation steps have to be carried out before the analysis proper.

Don?? compromise on quality
The first step is always the thorough homogenization of the tablet in a suitable solvent mixture. Depending on the determination technique applied, steps such as additional dilution or pipetting are required. In many labs these steps are carried out manually, which is not only time-consuming, but can result in carryover and erratic results.

815 Robotic Soliprep increases throughput and improves reproducibility
Using Metrohm's 815 Robotic Soliprep, these problems are all solved by an automated system that performs every sample preparation in exactly the same way. The content of the active ingredient in a single tablet as well as the product conformity of the whole batch can be determined in a fully automated process.