Confocal Imaging System Promises to Uncover New Therapeutic Drug Targets for University Research Group

Using Nikon confocal imaging systems, researchers from the Department of Physiology at Queen’s University in Belfast are hoping to identify whether recently discovered novel interstitial cells represent potential new targets for the development of effective therapies to treat urinary incontinence.

The purchase of a 90i microscope and C1 plus confocal system, has enabled the team to advance their study of cellular signalling within the bladder and lower urinary tract.

“The nature of the morphological studies we undertake meant we required an imaging system that had the ability to optically section tissue and visualise structures deep within the preparations” says Dr Karen McCloskey, Senior Lecturer at the Department of Physiology at Queen’s University, Belfast. “In addition, the Nikon confocal imaging system enables us to carry out minimally invasive investigations in living cells and tissues without significantly compromising normal cellular activity” she continued.

The modular set-up of the Nikon confocal systems allows for maximum flexibility, with researchers able to add further options at a later date. “The high numerical apertures and long working distances of the objective lenses make this equipment ideal for our specific applications,” Dr McCloskey added. It was also advantageous that the Nikon 90i and C1 plus confocal system were compatible with existing, established apparatus.

The imaging systems have now been up and running in Dr McCloskey’s department for eight months “We are extremely happy with its performance and the excellent support from our local representative and Nikon’s technical staff. Furthermore the opportunity to join the Partner in Research Programme with Nikon has provided added value to our initial purchase,” concluded Karen McCloskey.