GPC/SEC characterisation of copolymers and conjugated proteins

The Tetra Detector System from Viscotek provides a unique tool for characterising complex molecules including copolymers and conjugated proteins.

Combining the power of RI, UV, Viscometry and Low Angle Light Scattering (LALS) detectors acting together, with each detector providing complimentary but different information, the Tetra Detector is the most powerful GPC/SEC system available today. When integrated with the GPCmax (pump, autosampler, degasser) and OmniSEC software the Tetra Detector system is able to cope with even the most demanding analyses.

By ratioing the response from the two concentration detectors the system corrects the limitations of using a single detector by delivering rapid determination of a true copolymer or conjugated protein concentration profile. Using the viscometry and LALS detectors the Tetra Detector system enables users to obtain absolute molecular weight, molecular size (to less than 1 nm) and intrinsic viscosity as well as information on branching, conformation, aggregation and composition from their sample. Maintained in a thermostatically controlled environment the TDA has the sensitivity and stability to repeatably characterise copolymers and conjugated proteins even at low concentrations.

Founded in 1985, Viscotek GPC / SEC detectors, software and systems are in daily use in 1000's of leading research, quality control and process development laboratories worldwide. Over the years Viscotek has built an online reference list of several hundred customer technical articles covering applications of GPC/SEC technology, peptide and protein analysis, flow injection polymer analysis and dilute solution viscometry.

A pdf brochure describing the Tetra Detector system in more detail can be downloaded from the article webpage.